Systems biology: organisms as integrated networks, not isolated parts. Metabolic network: nodes=metabolites, edges=reactions. Flux balance analysis (FBA): steady-state, max objective (biomass). Stoichiometric matrix S: S·v=0 (steady state). Linear programming: max c^T v subject to S·v=0, lb≤v≤ub. COBRA toolbox. Gene regulatory networks: Boolean models (Kauffman), ODE models. Protein interaction networks: PPI, hub proteins. Omics layers: genomics, transcriptomics, proteomics, metabolomics,...
- systems-biology
- metabolomics
- omics